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1

Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion

Jean L. Grem, Mary Quinn, Abdel Ismail, Chris H. Takimoto, Richard Lush, David J. Liewehr, Seth M. Steinberg, Frank M. Balis, Alice P. Chen, Brian P. Monahan, Nancy Harold, William Corse, Janet Pang,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 243 KB

english, 2001

2

Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

Hidalgo, Manuel, Siu, Lillian L., Nemunaitis, John, Rizzo, Jinee, Hammond, Lisa A., Takimoto, Chris, Eckhardt, S. Gail, Tolcher, Anthony, Britten, Carolyn D., Denis, Louis, Ferrante, Karen, Von Hoff,

Journal:

Journal of Clinical Oncology

Year:

2001

File:

PDF, 720 KB

2001

3

Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography

Chris H. Takimoto, Raymond W. Klecker, William L. Dahut, Lorrin K. Yee, John M. Strong, Carmen J. Allegra, Jean L. Grem

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1994

Language:

english

File:

PDF, 487 KB

english, 1994

4

Foreword

Chris H. Takimoto

Journal:

Current Problems in Cancer

Year:

2005

Language:

english

File:

PDF, 24 KB

english, 2005

5

Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography

Elizabeth B. Agnew, Richard H. Wilson, Jean L. Grem, Leonard Neckers, Daoqin Bi, Chris H. Takimoto

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

6

Measurement of plasma uracil using gas chromatography–mass spectrometry in normal individuals and in patients receiving inhibitors of dihydropyrimidine dehydrogenase

Daoqin Bi, Lawrence W. Anderson, Jeremy Shapiro, Alla Shapiro, Jean L. Grem, Chris H. Takimoto

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2000

Language:

english

File:

PDF, 165 KB

english, 2000

7

Anticancer drug development at the US National Cancer Institute

Chris H. Takimoto

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

8

Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study

Jordi Rodon, Mitchell Garrison, Lisa A. Hammond, Johann de Bono, Lon Smith, Leonardo Forero, Desirée Hao, Chris Takimoto, John M. Lambert, Lini Pandite, Maria Howard, Hongsheng Xie, Anthony W. Tolcher

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

9

Safety and anti-tumor activity of sorafenib (Nexavar®) in combination with other anti-cancer agents: a review of clinical trials

Chris H. Takimoto, Ahmad Awada

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

10

Phase 0 clinical trials in oncology: a paradigm shift for early drug development?

Chris H. Takimoto

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 271 KB

english, 2009

11

Phase I study of paclitaxel poliglumex administered weekly for patients with advanced solid malignancies

Monica Mita, Alain Mita, John Sarantopoulos, Chris H. Takimoto, Eric K. Rowinsky, Ofelia Romero, Patrizia Angiuli, Cecilia Allievi, Amy Eisenfeld, Claire F. Verschraegen

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 404 KB

english, 2009

12

Phase I and pharmacokinetic study of cisplatin and troxacitabine administered intravenously every 28

Chia-Chi Lin, Muralidhar Beeram, Eric K. Rowinsky, Chris H. Takimoto, Chee M. Ng, Charles E. Geyer, Louis J. Denis, Johann S. De Bono, Desiree Hao, Anthony W. Tolcher, Sun-Young Rha, Jacques Jolivet,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 444 KB

english, 2009

13

A pharmacokinetic and safety study of intravenous arsenic trioxide in adult cancer patients with renal impairment

Christopher J. Sweeney, Chris Takimoto, Leslie Wood, Jennifer M. Porter, William G. Tracewell, Mona Darwish, Denise M. D’Andrea, Scot C. Remick

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 289 KB

english, 2010

14

Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors

Muhammad Wasif Saif, John Sarantopoulos, Amita Patnaik, Anthony W. Tolcher, Chris Takimoto, Murali Beeram

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 224 KB

english, 2011

15

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study

Ticiana B. Leal, Scot C. Remick, Chris H. Takimoto, Ramesh K. Ramanathan, Angela Davies, Merrill J. Egorin, Anne Hamilton, Patricia A. LoRusso, Stephen Shibata, Heinz-Josef Lenz, James Mier, John Sara

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 397 KB

english, 2011

16

The effect of bexarotene on atorvastatin pharmacokinetics: results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer

Heather A. Wakelee, Chris H. Takimoto, Arturo Lopez-Anaya, Quincy Chu, Gary Middleton, David Dunlop, Rodryg Ramlau, Natasha Leighl, Eric K. Rowinsky, Desiree Hao, Petr Zatloukal, Charlotte D. Jacobs,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 393 KB

english, 2012

17

A phase I pharmacokinetic study of bexarotene with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer (NSCLC)

Jordi Rodon, Charlotte D. Jacobs, Quincy Chu, Eric K. Rowinsky, Arturo Lopez-Anaya, Chris H. Takimoto, Heather A. Wakelee

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 277 KB

english, 2012

18

Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan

Aida A. Guemei, Jeff Cottrell, Roger Band, Hilary Hehman, Mike Prudhomme, Michael V. Pavlov, Jean L. Grem, Abdel Salam Ismail, Donnell Bowen, Robert E. Taylor, Chris H. Takimoto

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 125 KB

english, 2001

19

Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

Jean L. Grem, Lorrin K. Yee, David J. Venzon, Chris H. Takimoto, Carmen J. Allegra

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

20

Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primates

Susan M. Blaney, Chris Takimoto, Daryl J. Murry, Nancy Kuttesch, Cynthia McCully, Diane E. Cole, Karen Godwin, Frank M. Balis

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 375 KB

english, 1998

21

A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer

Jaffer A. Ajani, Chris Takimoto, Carlos R. Becerra, Alejandro Silva, Luis Baez, Allen Cohn, Pierre Major, Makio Kamida, Kevie Feit, Robert De Jager

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

22

Maximum tolerated dose: clinical endpoint for a bygone era?

Chris H. Takimoto

Journal:

Targeted Oncology

Year:

2009

Language:

english

File:

PDF, 108 KB

english, 2009

23

Foreword

Chris H.M. Takimoto

Journal:

Current Problems in Cancer

Year:

2007

Language:

english

File:

PDF, 18 KB

english, 2007

24

Foreword

Chris H. Takimoto

Journal:

Current Problems in Cancer

Year:

2006

Language:

english

File:

PDF, 21 KB

english, 2006

25

The Clinical Development of 9-Aminocamptothecin

CHRIS H. TAKIMOTO, REBECCA THOMAS

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 304 KB

english, 2000

26

A phase I and pharmacokinetic study of the nonpolyglutamatable thymidylate synthase inhibitor ZD9331 plus docetaxel in patients with advanced solid malignancies

Garry H. Schwartz, Christopher B. Jones, Mitchell Garrison, Amita Patnaik, Chris Takimoto, Heather McCreery, Michael Skinner, Anthony W. Tolcher, Eric K. Rowinsky

Journal:

Investigational New Drugs

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

27

Doege-Potter syndrome

Haider Zafar, Chris H. Takimoto, Geoffrey Weiss

Journal:

Medical Oncology

Year:

2003

Language:

english

File:

PDF, 104 KB

english, 2003

28

The clinical pharmacology of the oral fluoropyrimidines

Chris H Takimoto

Journal:

Current Problems in Cancer

Year:

2001

Language:

english

File:

PDF, 333 KB

english, 2001

29

Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the national cancer institute organ dysfunction working group

Chris H Takimoto, Scot C Remick, Sunil Sharma, Sridhar Mani, Ramesh K Ramanathan, James H Doroshow, Anne Hamilton, Daniel Mulkerin, Martin Graham, Graham F Lockwood, Percy Ivy, Merrill Egorin, Denis G

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 112 KB

english, 2003

30

Clinical applications of the camptothecins

Chris H. Takimoto, John Wright, Susan G. Arbuck

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1998

Language:

english

File:

PDF, 215 KB

english, 1998

31

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

Pienta, Kenneth J., Machiels, Jean-Pascal, Schrijvers, Dirk, Alekseev, Boris, Shkolnik, Mikhail, Crabb, Simon J., Li, Susan, Seetharam, Shobha, Puchalski, Thomas A., Takimoto, Chris, Elsayed, Yusri, D

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 232 KB

english, 2013

32

Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity

Chris H. Takimoto, Yu Ying Tan, Edwin C. Cadman, R.Douglas Armstrong

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 705 KB

english, 1987

33

Chronomodulated chemotherapy for colorectal cancer: Failing the test of time?

Chris H. Takimoto

Journal:

European Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

34

Pharmacokinetics and pharmacodynamic biomarkers in early oncology drug development

Chris H. Takimoto

Journal:

European Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 56 KB

english, 2009

35

Principles of Clinical Pharmacology || Non-Clinical Drug Development

Takimoto, Chris H.

Year:

2012

Language:

english

File:

PDF, 378 KB

english, 2012

36

Epidermal Growth Factor Receptor and Other Molecular Targets in the Treatment of Cancer

Chris H. Takimoto

Journal:

Clinical Colorectal Cancer

Year:

2003

Language:

english

File:

PDF, 47 KB

english, 2003

37

Commentary on “Thymidylate Synthase Pharmacogenetics in Colorectal Cancer”

Chris H. Takimoto

Journal:

Clinical Colorectal Cancer

Year:

2001

Language:

english

File:

PDF, 42 KB

english, 2001

38

9-Aminocamptothecin and Beyond : Preclinical and Clinical Studies

MILAN POTMESIL, SUSAN G. ARBUCK, CHRIS H. TAKIMOTO, LEONARD LIEBES, HOWARD HOCHSTER

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 953 KB

english, 1996

39

Clinical Pharmacology of 9-Aminocamptothecin

CHRIS H. TAKIMOTO, WILLIAM DAHUT, NANCY HAROLD, HAJIME NAKASHIMA, RONALD LIEBERMAN, MICHAEL D. LIANG, SUSAN G. ARBUCK, ALICE P. CHEN, J. MICHAEL HAMILTON, LOUIS R. CANTILENA, CARMEN J. ALLEGRA, JEAN L

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 165 KB

english, 1996

40

Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro

Chu, Edward, Takimoto, Chris H., Voeller, Donna, Grem, Jean L., Allegra, Carmen J.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.77 MB

english, 1993

41

Recombinant Sendai Virus as a Novel Vaccine Candidate for Respiratory Syncytial Virus

Takimoto, Toru, Hurwitz, Julia L., Zhan, Xiaoyan, Krishnamurthy, Sateesh, Prouser, Cecilia, Brown, Brita, Coleclough, Chris, Boyd, Kelli, Scroggs, Ruth A., Portner, Allen, Slobod, Karen S.

Journal:

Viral Immunology

Year:

2005

Language:

english

File:

PDF, 623 KB

english, 2005

42

Metabolism of patupilone in patients with advanced solid tumor malignancies

Kelly, Kevin R., Zollinger, Markus, Lozac’h, Frédéric, Tan, Eugene, Mita, Alain, Waldmeier, Felix, Urban, Patrick, Anand, Suraj, Wang, Yanfeng, Swart, Piet, Takimoto, Chris, Mita, Monica

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 285 KB

english, 2013

43

Caffeine/magnesium salicylate overdose

Kelly, Kevin R., Zollinger, Markus, Lozac’h, Frédéric, Tan, Eugene, Mita, Alain, Waldmeier, Felix, Urban, Patrick, Anand, Suraj, Wang, Yanfeng, Swart, Piet, Takimoto, Chris, Mita, Monica

Journal:

Reactions Weekly

Year:

2013

Language:

english

File:

PDF, 136 KB

english, 2013

44

Heat shock protein and proteasome targeting agents

Takimoto, Chris H, Diggikar, Shrinivas

Journal:

Hematology/Oncology Clinics of North America

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

45

A study on the preparation and rearrangement of the halogenated closo-carboranes ClnC2B4H6-n (n = 1,2) and ClnC2B5H7-n (n = 1,2)

Takimoto, Chris, Siwapinyoyos, Gowit, Fuller, Keith, Fung, Alexander P., Liauw, Ling, Jarvis, Wiley, Millhauser, Glenn, Onak, Thomas

Journal:

Inorganic Chemistry

Year:

1980

Language:

english

File:

PDF, 571 KB

english, 1980

46

Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data

Fetterly, Gerald J., Aras, Urvi, Meholick, Patricia D., Takimoto, Chris, Seetharam, Shobha, McIntosh, Thomas, de Bono, Johann S., Sandhu, Shahneen K., Tolcher, Anthony, Davis, Hugh M., Zhou, Honghui,

Journal:

Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

47

Identification of an RNA Binding Site for Human Thymidylate Synthase

Edward Chu, Donna Voeller, David M. Koeller, James C. Drake, Chris H. Takimoto, Gladys F. Maley, Frank Maley and Carmen J. Allegra

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 971 KB

english, 1993

48

Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing

Nikanjam, Mina, Stewart, Clinton F., Takimoto, Chris H., Synold, Timothy W., Beaty, Orren, Fouladi, Maryam, Capparelli, Edmund V.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 872 KB

english, 2015

49

Respiratory Syncytial Virus Infections on an Adult Medical Ward

Takimoto, Chris H.

Journal:

Archives of Internal Medicine

Year:

1991

Language:

english

File:

PDF, 370 KB

english, 1991

50

Encyclopedia of Cancer || Camptothecins

Takimoto, Chris H.

Year:

2002

Language:

english

File:

PDF, 119 KB

english, 2002